Jonathan Grigg

Jonathan Grigg

Title: Professor
BSc, MB.BS. MD, MRCP, FRCPCH.
Professor of Paediatric Respiratory and Environmental Medicine

Research Activity:

  • Randomised controlled trials of therapies for wheezing diseases in children
  • Mechanisms for particulate-pollution induced vulnerability to infection in children
  • Children's environmental health research

Bio


Previously at the Department of Child Health, University of Leicester, Professor Grigg's area of research lies in the mechanisms of respiratory disease in children, and new treatments for wheezing disorders in young children. He is particularly interested in the hidden adverse costs of air pollution and how environmental factors, such as particles of carbon from exhaust pipes, impact on lung growth. By measuring, for example, carbon content in the lower airway cells of children aged between 7 and 18 years, Professor Grigg and his team have found that higher levels of carbon equate to lower levels of lung function. He is also investigating the mechanism underlying the increased vulnerability to pneumonia in children exposed to air pollution in the developing world. (Indoor smoke is an additional factor here - over two million children a year die as a result of an increased susceptibility to infection). This represents a new area of research, and is the first phase of a strategy to link an understanding of basic mechanisms to effective exposure reduction in the field (see http://www.bbc.co.uk/programmes/p01dgd9c/features/pollution). Professor Grigg is also looking at ways in which children might be protected from these effects - for example the development of new stove designs in Guatemala , and biogas stoves in India.

More broadly, Professor Grigg has plans to develop a Centre for Children's Environmental Health at Queen Mary. There are several in the US and Canada but none in the UK . At its core will be programme of clinical research with the strategic aim of reducing environmental threats to children's health in the UK .

May 1992 - Feb 1993 Postdoctoral Research Fellow, Department of Pediatric Leukocyte Biology, Baylor College of Medicine, Houston, Texas, USA

Mar 1993 - Jul 1995 Thoracic Fellow, Department of Thoracic Medicine, The Royal Children's Hospital, Melbourne, Australia

Sep 1995 - Jan 1996 Locum Paediatric Senior Registrar posts.

Feb 1996 - Apr 1997 Paediatric Senior Registrar Department of Paediatrics, St. Mary's Hospital, London

May 1997 - Mar 2006 Senior Lecturer in Paediatric Respiratory Medicine, Department of Child Health, University of Leicester

Publications

Panickar J, Lakhanpaul M, Lambert PC, Kenia P, Stephenson T, Smyth A, Grigg J. A Randomized, Controlled Trial of Oral Prednisolone for Preschool Children Hospitalized with Acute Viral-Wheeze. New England Journal of Medicine 2009;360;329-338

Grigg J, Savill J, Haslett C, Saraff C, Silverman M. Neutrophil apoptosis and clearance by macrophages in the lungs of neonates with pulmonary inflammation. Lancet 1991;338:720-722

Grigg J, Barber A, Silverman M. Increased levels of bronchoalveolar lavage fluid Interleukin-6 in preterm ventilated infants after prolonged rupture of membranes. American Review of Respiratory Disease 1992;145:782-786.

Grigg J, Kukielka G L, Berens K L, Dryer W J, Entman M L, Smith C W. Induction of intercellular adhesion molecule-1 by lipopolysaccharide in canine alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology 1994;11:304-311.

Bunn HJ, Dinsdale D, Smith T, Grigg J. Ultrafine particles in alveolar macrophages from normal children. Thorax 2001:56:932-934. Oommen A, McNally T, Grigg J . Eosinophil activation in preschool viral-wheeze. Thorax. 2003;58:876-879.

Oommen A, Lambert PC, Grigg J. Efficacy of a short course of oral prednisolone for viral-wheeze in children aged 1-5 years: randomised controlled trial. Lancet. 2003;362:1433-1438.

Kulkarni NS , Prudon B, Panditi SL, Abebe Y, Grigg J. Carbon loading of alveolar macrophages in adults and children exposed to biomass smoke particles. Science of the Total Environment. 2005;345:23-30

Mudway IS, Duggan ST ,Venkataraman, Kelly FJ, Grigg J. Combustion of the biomass fuel dung cake results in the generation of highly redox active fine particulates. Particle and Fibre Toxicology. 2005;2:6 (1-11)

Pierse N, Rushton L, Harris R, Kuehni CE, Silverman M, Grigg J. Locally-generated particulate pollution and respiratory symptoms in young children. Thorax. 2006. 61:216-20.

Kulkarni N, Pierse N, Rushton L, Grigg J. Carbon in airway macrophages and lung function in children. New England Journal of Medicine . 2006 Jul 6;355(1):21-30

 


View all Jonathan Grigg's Research Publications at: http://www.researchpublications.qmul.ac.uk


Contact

Centre for Genomics and Child Health
Blizard Institute
Barts and The London School of Medicine and Dentistry
Blizard Building
4 Newark Street
Whitechapel
London E1 2AT

 

 

020 7882 2206
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